Stabilized solid pharmaceutical preparation and method of produc

Details Stabilized solid pharmaceutical preparation and method of produc Stabilized solid pharmaceutical preparation and method of produc

1994-07-15

1998-04-14

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514653, A61K 3119, A61K 31135

Patent

active

057391653

ABSTRACT:
A solid pharmaceutical preparation containing 5 to 50% by weight of ibuprofen and 0.1 to 10% by weight of phenylpropionamide or a pharmaceutically acceptable salt thereof which are stabilized. The solid pharmaceutical preparation can be produced by means of granulating with carriers at least one active ingredient, preferably both ingredients separately into the ibuprofen group and the phenylpropanolamine group, and mixing the former with the latter to enhance the stability of the active ingredients. Preferably, in the phenylpropanolamine group, the amount of any reducing sugar is minimized to such an extent as to maintain the stability of the active ingredient. The above pharmaceutical preparation is suitable for a cold remedy, which has a more excellent pharmacological activity based on ibuprofen, less decomposability of phenylpropanolamine and less change of external appearance of the preparation due to low compatibility between phenylpropanolamine and ibuprofen. Therefore, the pharmaceutical preparation has a longer period of quality assurance.

REFERENCES:
patent: 5025019 (1991-06-01), Sunshine et al.
Dittert, Sprowls' American Pharmacy, Seventh Edition, p. 334, 1985.

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