Stabilized solid pharmaceutical composition containing acid addi

Details Stabilized solid pharmaceutical composition containing acid addi Stabilized solid pharmaceutical composition containing acid addi

1994-02-09

1995-08-15

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424499, A61K 920

Patent

active

054417473

ABSTRACT:
Disclosed are stabilized dry chemical (e.g. pharmaceutical) compositions containing the water soluble acid addition salt of a poorly soluble basic compound (e.g. mianserin, apomorphine, chlorpromazine, imipramine, or promethazine); an excipient selected from the group consisting of microcrystalline cellulose, lactose, calcium hydrogen phosphate, and mixtures thereof; and a water soluble (>2 mg/ml) alkaline stabilizer. The resulting dry composition are relatively more bioavailable and stable than compositions not containing the water soluble alkaline stabilizer, especially after high temperature (>45.degree.) granulation processes. The process for preparing the dry composition is also more "rugged" with the added water soluble alkaline stabilizer.

REFERENCES:
patent: 2018410 (1935-10-01), McDonald et al.
patent: 2287699 (1942-06-01), Moss et al.
patent: 3012852 (1961-12-01), Nelson
patent: 3411873 (1968-11-01), Harnisch et al.
patent: 4743450 (1990-05-01), Harris et al.
patent: 4834985 (1989-05-01), Elger et al.
patent: 5066495 (1991-11-01), Moro et al.
patent: 5096714 (1992-03-01), Kuhrts
patent: 5102666 (1992-04-01), Acharya

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