Stabilized solid form choline salicylate compositions

Details Stabilized solid form choline salicylate compositions Stabilized solid form choline salicylate compositions

1976-07-14

1978-01-10

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424233, 424234, A61K 3160, A61K 31615, A61K 3161

Patent

active

040679748

ABSTRACT:
Choline salicylate is stabilized in solid form by means of a metal salicylate having a valence of at least 2, preferably aluminum, bismuth, calcium or magnesium salicylate. The composition is stabilized to a still greater degree by the addition thereto of carboxy-methyl cellulose. A still greater degree of stabilization is achieved by forming a complex of the choline salicylate, metal salicylate and carboxy-methyl cellulose. The complex is formed by preparing a solution of the carboxy-methyl cellulose, choline salicylate and metal salicylate, permitting complexng reaction to take place and drying. All of these stabilized forms of choline salicylate are used in solid dosage forms such as granules, tablets, capsules and supporitories for administration to animals and humans, in the course of choline salicylate therapy, to elevate the blood levels of salicylate ion.

REFERENCES:
patent: 3326760 (1967-06-01), Halpern et al.
patent: 3347744 (1967-10-01), Latshaw et al.
patent: 3759980 (1973-09-01), Rosen et al.

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