Stabilized solid dosage forms of choline metal carboxymethylcell

Details Stabilized solid dosage forms of choline metal carboxymethylcell Stabilized solid dosage forms of choline metal carboxymethylcell

1991-06-17

1993-06-08

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514165, 514781, 514960, 514970, A61K 3160, A61K 4700

Patent

active

052179656

ABSTRACT:
The stability of compositions of choline salicylate-metal salicylate-carboxymethylcellulose is improved by the incorporation therein of microcrystalline cellulose. The microcrystalline cellulose is linked to the remainder of the composition by liquid bridges and is preferably present in an amount of about 2.5-25% by weight. The microcrystalline cellulose enhances the stability of the composition and thereby enhances solid dosage forms thereof such as tablets, capsules, suppositories and granules.

REFERENCES:
patent: 4067974 (1978-01-01), Sasmor
patent: 5043168 (1991-08-01), Patel
Chemical Abstracts 109(18):156086(n) Rowe.
Chemical Abstracts 106(24): 201635(s)-Vander Watt.

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