Stabilized ribozyme analogs

Details Stabilized ribozyme analogs Stabilized ribozyme analogs

1994-12-22

1996-08-13

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 5, C07H 2104, C12Q 168, C12Q 170, A61K 4800

Patent

active

055457290

ABSTRACT:
Disclosed are stabilized ribozyme analogs having the ability to endonucleolytically cleave a sequence of 3' to 5' linked ribonucleotides. These ribozyme analogs include modifications at specific loop, catalytic core, and flanking region nucleotides which makes them more resistant to nucleases. Also disclosed are methods of preparing and utilizing the ribozyme analogs of the invention, and pharmaceutical formulations and kits containing such ribozyme analogs.

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