Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Patent
1994-09-15
1997-04-01
Guzo, David
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
4351723, C12N 701, C12N 510
Patent
active
056164874
ABSTRACT:
The present invention provides a stabilized virus, which is modified using a stabilizing agent. The invention also provides a process for producing a stabilized virus by culturing viral producing cells with a stabilizing agent at a temperature below 37.degree. C. The invention further provides methods to introduce an exogenous nucleotide sequence into a cell using a stabilized virus containing the exogenous nucleotide sequence. The invention also provides methods for administering an exogenous nucleotide sequence to a subject using a stabilized virus containing the exogenous nucleotide sequence. The invention further provides a method to produce a protein by infecting a cell with a stabilized virus containing a exogenous nucleotide sequence encoding the protein and then isolating the protein produced by the infected cells.
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Eisfeld Timothy M.
Palsson Bernhard O.
Aastrom Biosciences, Inc.
Guzo David
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