Stabilized radiolabelled compounds

Details Stabilized radiolabelled compounds Stabilized radiolabelled compounds

1986-04-25

1988-12-27

Terapane, John F.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

436 8, 436 18, 252645, 252402, 252403, A61K 4902, G01N 3348, G01N 3350, C09K 1530

Patent

active

047939877

ABSTRACT:
A stabilizer for radioactively labelled organic compounds has the general formula ##STR1## where R is C1 to C4 alkylene which may be OH substituted, m is 0 or 1 (i.e. R may be absent or present), X is carboxyl or sulphonyl e.g. COOH or SO.sub.3 H or a salt thereof and n is 1, 2 or 3. Radiolabelled compounds of biological origin, such as nucleotides and amino acids, may be stabilized either in solution or in the freeze-dried state. For example, L-[.sup.35 S]methionine may be stabilized to prevent formation of a 47 KD band in protein transcription/translation experiments.

REFERENCES:
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patent: 4390517 (1983-06-01), O'Brien et al.
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patent: 4440738 (1984-04-01), Fauzi et al.
patent: 4510125 (1985-04-01), Grogg et al.
Ostrovskii et al., CA 73:85172n (1970).
Tmenov et al., CA 90:202436r (1979).
CA 100: 140230h (1984).
Koyama, CA 83: 96435 (1975).

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