Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1981-01-15
1982-06-15
Rosen, Sam
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 19, 424305, 424317, A61K 900, A61K 31215, A61K 3119
Patent
active
043350976
ABSTRACT:
The invention relates to stabilized, prostaglandin-containing tablets with controlled rate of solubility, for local use and a process for the preparation thereof. The tablets according to the invention comprise 0.2 to 20% by weight of one or more natural or synthetic prostaglandins, 0.4 to 40% by weight of a non-toxic buffer, which adjusts the pH of the liquid film formed on the surface of the solid phase due to air humidity, to 3 to 5, 1 to 50% by weight of stearic acid, 0 to 15% by weight of an alkali earth metal stearate, 10 to 95% by weight of lactose and/or mannite, 0 to 15% by weight of a further granulation aid, 1 to 30% by weight of a disintegrating agent and optionally 0.5 to 10% by weight of a flavoring and aroma substance and are prepared under a pressure of 500 to 2000 kp./cm.sup.2. (49.03 to 196.13 MPa).
REFERENCES:
patent: 3937801 (1976-02-01), Lippmann
Lippert--Chem. Abst. vol. 82, (1975) p. 610s.
David Agoston
Horvath Tibor
Kiss Csaba
Nagy Gabor
Simon Kalman
Chinoin Gyogyszer - es Vegyeszeti Termekek Gyara Rt.
Rosen Sam
Ross Karl F.
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