Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-05-23
2006-05-23
Parkin, Jeffrey S. (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S208100
Reexamination Certificate
active
07048929
ABSTRACT:
A modified polypeptide corresponding to an envelope glycoprotein of a primate lentivirus is described. The polypeptide has been modified from the wild-type structure so that it has cysteine amino acid residues introduced to create disulfide bonds, a cavity is filled with hydrophobic amino acids, a Proresidue is introduced at a defined turn structure of the protein, or the hydrophobicity is increased across the interface between different domains, while retaining the overall 3-dimensional structure of a discontinuous conserved epitope of the wild-type protein. Preferably, the polypeptide has more than one of those characteristics. Preferably, the primate lentivirus is HIV, and the protein is HIV-1 gp120.
REFERENCES:
patent: 5817316 (1998-10-01), Sodroski et al.
Freed, E. O., et al., 1991, “Identification of the principle neutralizing determinant of human immunodeficiency virus type 1 as a fusion domain.”, J. Virol. 65(1):190-194.
McKeating, J. A., et al., 1992, “Amino acid residues of the human immunodeficiency virus type 1 gp120 critical for the binding of rat and human neutralizing antibodies that block that gp120-sCD4 interaction.”, Virol. 190:134-142.
Thali, M., et al., 1993, “Characterization of conserved human immunodeficiency virus type 1 and gp120 neutralization epitopes exposed upon gp120-CD4 binding.”, J. Virol. 67(7):3978-3988.
Sullivan, N., et al., 1993, “Effect of amino acid changes in the V1/V2 region of the human immunodeficiency virus type 1 gp120 glycoprotein on subunit association, syncytium formation, and recognition by a neutralizing antibody.”, J. Virol. 67(6):3674-3679.
Cao, J., et al., 1993, “Effects of amino acid changes in the extracellular domain of the human immunodeficiency virus type 1 gp41 envelope glycoprotein.”, J. Virol. 67(5):2747-2755.
Alkhatib, G., et al.,Science272:1955-1958 (1996).
Allan, JS., et al.,Science228:1091-1093 (1985).
Altschul, SF., et al.,Nucleic Acids Res.25: 3389-3402 (1997).
Arendrup, et al.,J. AIDS5:303-307 (1992).
Arthos, J., et al.,Cell57:469 (1989).
Baggioline, M., et al.,Adv. Immunol.55:97-179 (1994).
Barre-Sinousi, F., et al.,Science220:868-871 (1983).
Berkower, et al.,J. Exp. Med.170:1681-1695 (1989).
Berman, PW., et al.,Nature345:622-625 (1990).
Binley, J., et al.,AIDS Res. Hum. Retroviruses,14:191-198 (1997).
Bolmstedt, A., et al.,J. AIDS12:213-220 (1996).
Brodsky, MH., et al.,J Immunol.144:3078-3086 (1990).
Bruck, et al.,Vaccine12:1141-1148 (1994).
Bullough, P., et al.,Nature371:37-43 (1994).
Burton, et al.,Science266:1024-1027 (1994).
Cao, J., et al.,J. Virol.71:9808-9812 (1997).
Carr, CM., et al.,Cell73:823-832 (1993).
Chan, DC., et al.,Cell89:263-273 (1997).
Chen, CH., et al.,J. Virol.69:3771-3777 (1995).
Chen, Z., et al.,J. Virol.71:2705-2714 (1997).
Cheng-Mayer, C., et al.,Science240:80-82 (1988).
Choe, H., et al.,Cell85:1135-1148 (1996).
Clark, SJ, et al.,N. Engl. J. Med.324:950-960 (1991).
Cocchi, F., et al.,Nature Med.2:1244-1247 (1996).
Cocchi, F., et al.,Science270:1811-1815 (1995).
Connor, R., et al.,J. Exp. Med.185:628 (1997).
Connor, RI., et al.,J. Virol.67:1772-1778 (1993).
Coombs, RW., et al.,N. Engl. J. Med.321:1626-1631 (1989).
Cordonnier, A., et al.,Nature340:571-574 (1989).
D'Souza, et al.,J. Infect. Dis.175: 1056-1062 (1997).
Daar, ES., et al.,N. Engl. J. Med.324:961-964 (1991).
Daar, et al.,Proc. Natl. Acad. Sci.USA 87:6574-6578 (1990).
Dalgleish, AG., et al.,Nature312:763-767 (1984).
Dalum, et al.,Mol. Immunol.34:1113-1120 (1997).
Davidson, et al.,Nat. Genet3:219 (1993).
Dean, M., et al.,Science273:1856-1862 (1996).
Dempsey, P., et al.,Science271:348-350 (1996).
Deng, HK., et al.,Nature381:661-666 (1996).
Doranz, BJ., et al.,Cell85:1149-1158 (1996).
Dragic, T., et al.,Nature381:667-673 (1996).
Earl, PL., et al.,J. Virol.65:2047-2055 (1991).
Earl, PL., et al.,Proc. Natl. Acad. Sci. USA87:648-652 (1990).
Emini, et al.,Nature355:728-730 (1991).
Fauci, AS., et al.,Ann. Inter. Med.124:654-663 (1996).
Feng, Y., et al.,Science272:872-877 (1996).
Fenyo, E., et al.,J. Virol.62:4414-4419 (1988).
Freed, E., et al.,Proc. Natl. Acad. Sci. USA87:4650-4654 (1990).
Fung, et al.,J. Virol.66:848-856 (1992).
Gallo, RC., et al.,Science224:500-503 (1984).
Gegerfelt, et al.,Virology185:162-168 (1991).
Geller, AI., et al.,J. Neurochem64:487 (1995).
Geller, AI., et al.,Proc Natl. Acad. Sci. U.S.A.87:1149 (1990).
Geller, AI., et al.,Proc Natl. Acad. Sci. U.S.A.90:7603 (1993).
Gerard, N., et al.,Curr. Opin. Immunol.6:140-145 (1994).
Girard, et al.,Proc. Natl. Acad. Sci.USA 88:542-546 (1991).
Gorny, et al.,J. Virol.66:7538-7542 (1992).
Haigwood, et al.,AIDS Res. Hum. Retro.6:855-869 (1990).
Haigwood, et al.,J. Virol.66:172-182 (1992).
Ho, DD., et al.,N. Engl. J. Med.321:1621-1625 (1989).
Ho, et al.,J. Virol.65:489-493 (1991).
Javaherian, et al.,Science250:1590-1593 (1990).
Kang, et al.,Proc. Natl. Acad. Sci.USA 88:6171-6175 (1991).
Kaplitt, MG., et al.,Nat. Genet.8:148 (1994).
Karlsson, G., et al.,J. Virol.71:4218 (1997).
Klaniecki, et al.,AIDS Res. Hum. Retro.7:791-798 (1991).
Klatzmann, D., et al.,Nature London312:767-68 (1984).
Kowalski, M., et al.,Science237:1351-1355 (1987).
Lasky, L., et al.,Cell50:975-985 (1987).
LeGal LaSalle, et al.,Science259: 988 (1993).
Leonard, CK., et al.,J. Biol. Chem.265:10373-10382 (1990).
Liu, R., et al.,Cell86:367-378 (1996).
Lu, M., et al.,Nature Structural Biol.2:1075-1082 (1995).
Marcon, L., et al.,J. Virol.71:2522-2527 (1997).
Matthews, et al.,Proc. Nat. Acad. Sci.USA 83:9709-9713 (1986).
McKeating, et al.,J. Virol.67:4932-4944 (1993).
McKeating, et al.,Virology190:134-142 (1992).
Moebius, U., et al.,J. Exp. Med.176:507-517 (1982).
Moore, et al.,J. Virol.69:101-109 (1995).
Moore, et al.,J. Virol.67:6136-6151 (1993).
Moore, et al.,J. Virol.67:863-875 (1993).
Moore, et al.,J. Virol.69:122-133 (1995).
Moore, et al.,J. Virol.70:1863-1872 (1996).
Moore, J., et al.,J. Virol.68:469-484 (1994).
Moore, J., et al.,J. Virol.68:8350-8364 (1994).
Muster, et al.,J. Virol.67:6642-6647 (1993).
Myers, G., et al., “Human Retroviruses and AIDS: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences,”Los Alamos National Laboratory,(1994).
Nara, et al.,J. Virol.64:3779-3791 (1990).
Ohno, et al.,Proc. Natl. Acad. Sci.USA 88:10726-10729 (1991).
Olshevsky, U., et al.,J. Virol.64:5701-5707 (1990).
Peterson, A., et al.,Cell54:65-72 (1988).
Pinter, A., et al.,J. Virol.63:2674-2679.
Pollard, S., et al.,EMBO J.11:585-591 (1992).
Posner, et al.,J. Immunol.16:4325-4332 (1991).
Premack, BA., et al.,Nature Medicine11:1174-1178 (1996).
Profy, et al.,J. Immunol.144:4641-4647 (1990).
Roben, P., et al.,J. Virol.68:4821-4828 (1994).
Robey, W., et al.,Proc. Natl. Acad. Sci. USA83:7023-7027 (1986).
Robey, WG., et al.,Science228:593-595 (1985).
Robinson, J., et al.,AIDS Res. Hum. Retro6:567-580 (1990).
Rusche, et al.,Proc. Natl. Acad. Sci.USA 84:6924-6928 (1987).
Rusche, J., et al.,Proc. Natl. Acad. Sci. USA85:3198-3202 (1988).
Ryu, SE., et al.,Nature London348:419-425 (1990).
Samson, M., et al.,Nature382:722-725 (1996).
Sattentau, Q., et al.,J. Exp. Med.174:407-415 (1991).
Sattentau, Q., et al.,J. Virol.67:7388-7393 (1993).
Sawyer, et al.,J. Virol.67:1342-1349 (1994).
Schuitemaker, H., et al.,J. Virol.66:1354-1360 (1991).
Speck, R., et al.,J. Virol.71:7136-7139 (1997).
Starcich, BR., et al.,Cell45:637-648 (1986).
Steimer, et al.,Science254:105-108 (1991).
Sullivan, et al.,J. Virol.69:4413-4422 (1995).
Thali, et al.,J. Virol.65:6188-6193 (1991).
Thali, et al.,J. Virol.66:5635-5641 (1992).
Thali, M., et al.,J. Virol.67:3978-3988 (1993).
Tilley, et al.,Res. Virol.142:247-259 (1991).
Trkola, A., et al.,J. Virol.70:1100-1108 (1996).
Trkola, A., et al.,Nature384: 184-187 (1996).
Wang, J., et al.,Nature London348:411-418 (1990).
Watkins, B., et al.,J. Virol.67:7493 (1993).
Weissenhorn, W., et al.,EMBO J.15:1507-1514 (1996).
Weissenhorn, W., et al.,Nature387:426-430 (1997).
Wu, L., et al.,Nature384:179-183 (1996).
Wyatt, et al.,J. Virol.69:5723-5733 (1995).
Wyatt, R., et al.,J. Virol.67:4557-4565 (1993).
Wyatt, R., et al.,J. Virol.7
Farzan Michael
Hendrickson Wayne A.
Kwong Peter D.
Sodroski Joseph G
Wyatt Richard T.
Dana-Farber Cancer Institute Inc.
Nixon & Peabody LLP
Parkin Jeffrey S.
The Trustees of Columbia University in the City of New York
LandOfFree
Stabilized primate lentivirus envelope glycoproteins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stabilized primate lentivirus envelope glycoproteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized primate lentivirus envelope glycoproteins will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3530821