Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Reexamination Certificate
2003-08-19
2009-12-08
Richter, Johann R (Department: 1616)
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
C424S045000, C424S489000, C514S002600, C514S169000, C514S177000, C514S178000, C514S179000, C514S180000, C514S181000, C514S182000
Reexamination Certificate
active
07628978
ABSTRACT:
Stabilized dispersions are provided for the delivery of a bioactive agent to the respiratory tract of a patient. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a hydrofluoroalkane propellant. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as, by settling or flocculation. In particularly preferred embodiments, the stabilized dispersions may be administered to the lung of a patient using a metered dose inhaler.
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Dellamary Luis
Kabalnov Alexey
Schutt Ernest G.
Tarara Thomas E.
Weers Jeffry G.
Alstrum-Acevedo J. H.
Janah & Associates
Novartis Pharma AG
Richter Johann R
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