Stabilized polymeric thiol reagents

Details Stabilized polymeric thiol reagents Stabilized polymeric thiol reagents

2005-12-21

2010-12-14

Truong, Duc (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

C525S054100, C528S373000, C528S425000, C514S398000, C424S078270

Reexamination Certificate

active

07851565

ABSTRACT:
Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y—S—W]x, where POLY is a water soluble polymer; Y is a hydrocarbon-based spacer group, x is 1 to 25, and S—W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of such polymeric reagents with pharmaceutically relevant molecules, and methods of their formation and use.

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