Stabilized plasminogen activator precursor and method of produci

Details Stabilized plasminogen activator precursor and method of produci Stabilized plasminogen activator precursor and method of produci

1990-04-20

1991-12-24

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

435212, 435215, C12N 996, C12N 972

Patent

active

050752308

ABSTRACT:
A plasminogen activator precursor obtainable from a serum-free culture fluid of human kidney cells is stabilized by adding to its solution poly-C1-C5-alkylene glycols, polyethylene-polyoxypropylene copolymers, mandelic acid salts, triethanolamine, acid addition salts of acetylglycillysine methyl ester, guanidine salts, thiocyanic acid salts, alkali metal iodides or serine.

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patent: 4552760 (1985-11-01), Murakami et al.
Nonionic Surfactants, vol. 2, 1967, Chapter 3, pp. 44, 45, 74, 75; chapter 18, pp. 604-609.
Monsan, P. et al. (1984), Ann. N.Y. Acad. Sci. 434, 48-60.
Wun, T-C., et al. (1982), J. Biol. Chem. 257(12) 7262-7268.
Nielsen et al., Biochemistry 1982, vol. 21, pp. 6410-6415.

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