Organic compounds -- part of the class 532-570 series – Organic compounds – Fatty compounds having an acid moiety which contains the...
Reexamination Certificate
2000-05-22
2001-08-21
Carr, Deborah D. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Fatty compounds having an acid moiety which contains the...
C554S002000, C554S003000, C554S079000
Reexamination Certificate
active
06278004
ABSTRACT:
BACKGROUND OF THE INVENTION
The present invention is directed to a method for the stabilization of a phospholipidic composition, a method for the production of such a composition as well as the use of the stabilized phospholipidic composition.
Phospholipidic compositions have been known for a long time and are used in various ways in the field of food, in food for animals, in the cosmetic field as well as in the pharmaceutical field. Hereby, there is the problem however, that such phospholipidic compositions depending on the concentration of phospholipides and the respective use and being liquid, semisolid, as particularly gel-like, creamy, paste-like, or solid, develop an undesired inherent smell, particularly a rancid inherent smell when exposed to air and/or when stored.
In order to suppress this undesired change of odor of phospholipidic compositions, it is known, to provide the phospholipidic compositions with a stabilizer, whereby such stabilizers are built-up on the basis of vitamin C, vitamin E and/or their derivatives. Furthermore, according to the DE 41 41 842 A1, phospholipidic compositions can also be protected from an undesired oxidation by using N-acyl-phosphatidylethanolamine.
Furthermore the DE 40 21 082 A1 suggests methods which use urea, monosaccharides or mixtures of urea with monosaccharides for the stabilization of phospholipidic compositions.
The object of the present invention is to dispose a method for the stabilization of a phospholipidic composition by which phospholipidic compositions are stabilized in that way that, even when stored for a longer period of time and exposed to air, the odor does not change.
SUMMARY OF THE INVENTION
The inventive method for the stabilization of a phospholipidic composition provides that at least one stabilizer is added to the at least one phospholipide. In the inventive method phytic acid, a salt of the phytic acid and/or a phytic acid derivative, is added as stabilizer to the at least one phospholipidic.
Surprisingly it was observed that the phospholipidic compositions treated according to the inventive method and containing said phytic acid, said salt of the phytic acid and/or said phytic acid derivative as stabilizer, show an excellent stability even when stored under exposure to air, so that an undesired change of odor does not occur with the phospholipidic composition stabilized in such a way, even after a longer period of storage of several months. This leads to the fact that the phospholipidic composition stabilized according to the inventive method does not have to be stored like the other known phospholipidic compositions under inert gas, as for example nitrogen, at reduced temperatures, particularly temperatures around the freezing point. Correspondingly to that, reproducible resultant products regarding the concentration of the phospholipide can be manufactured from the compositions stabilized according to the inventive method, as for example creams, gels, ointments, dispersions, semisolid or liquid liposomal preparations, since the phospholipide concentration remains constant also after a longer storage period.
DETAILED DESCRIPTION OF THE INVENTION
A first embodiment of the composition stabilized according to the inventive method provides a composition that comprises as stabilizer a salt of the phytic acid, particularly an alkaline-earth salt and/or an alkaline salt of the phytic acid.
The phospholipidic composition stabilized according to the inventive method preferably comprises as stabilizer a calcium salt and/or a magnesium salt of the phytic acid, whereby also a mixture of calcium salt and magnesium salt cause a perfect stabilization of the phospholipidic composition.
The afore mentioned phytic acid, the salt of the phytic acid and/or the phytic acid derivative is either a synthetically produced product or a product gained from seed husks and/or from the aleurone layer of grain by the extraction with a watery system and/or with a corresponding solvent. Typical grain sorts from which the phytic acid, the salt of the phytic acid and/or the phytic acid derivative are obtained are wheat, oats, corn, rice, rye, barley and/or millet.
In respect to the derivatives of the phytic acid existing in the composition stabilized according to the inventive method particularly ester, ether, amides, amines and/or their salts are to be mentioned.
With regard to the weight ratio of the at least one phospholipide relative to the phytic acid, to the salt of the phytic acid and/or to the phytic acid derivative in the composition stabilized according to the inventive method, it is to be noted that this weight ratio depends, on one hand, on the desired stabilization and, on the other hand, on the corresponding use of the phospholipidic composition stabilized according to the inventive method.
In the composition stabilized according to the inventive method the weight ratio of the at least one phospholipide to the already described stabilizer normally varies between 1:0.08 to 1:0.002, preferably between 1:0.04 and 1:0.003. If the manufacturing of an extremely long storable phospholipidic composition is desired, then this embodiment comprises a relatively high stabilizer content. The same is the case for such embodiments which are processed as sun protecting products. In other words, by varying the amount of the afore mentioned stabilizers a desired storing stability of the inventive composition can thus be obtained.
With regard to the phospholipide existing in the composition stabilized according to the inventive method, it is to be noted that this is particularly a phospholipide or phospholipide mixture which is isolated from plants, preferably from soy beans.
It is particularly suitable, if the mixture of phospholipides existing in the composition stabilized according to the inventive method comprises at least 70% by weight of 1.2-diacylglycero-3-phosphatidylcholine.
In a further embodiment of the composition stabilized according to the inventive method the mixture of phospholipides existing in the composition comprises at least 76% by weight±3% by weight of 1.2-diacylglycero-3-phosphatidylcholine and 3% by weight±3% by weight of lyso-phosphatidylcholine.
Another, also suitable variation of the embodiment of the composition stabilized according to the inventive method provides that hereby the mixture of phospholipides is a mixture of phospholipides with a high content of phosphatidylcholine, and preferably comprises 93% by weight±3% by weight of 1.2-diacylglycero-3-phosphatidylcholine and particularly at least 96% by weight of 1.2-diacylglycero-3-phosphatidylcholine, whereby as a further phospholipide especially 3% by weight±3% by weight of lyso-phosphatidylcholine additionally exists.
In addition to the phosphatidylcholines already described, the composition stabilized according to the inventive method may also contain preferably 1.2-diacylglycero-3-phosphoethanolamine, 1.2-diacylglycero-3-phosphoinositol, 1.2-diacylglycero-3-phosphoserine, 1.2-diacylglycero-3-phosphoglycerol and 1.2-diacylglycero-3-phosphate as further phospholipides, depending on the respective basic material and the used isolation- and purification method.
A further preferred embodiment of the composition stabilized according to the inventive method comprises such a mixture of phospholipides in which the acyl groups (residues) of the phospholipides existing in the mixture and especially the acyl groups of the phosphatidylcholine provided in the mixture, consist of
61-73% by weight of the linoleic acid residue,
10-14% by weight of the palmitic acid residue,
8-12% by weight of the oleic acid residue,
4-6% by weight of the linolenic acid residue,
3-5% by weight of the stearic acid residue, and/or
2% by weight of other fatty acid residues.
Such a mixture of phospholipides or phosphatidylcholines or the mixtures described more precisely in the following, particularly show the advantages described above for the composition stabilized according to the inventive method, since such phospholipides, respectively such phosphatidylcholines,
Aventis Pharma Deutschland GmbH
Carr Deborah D.
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
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