Stabilized pharmaceutical compositions containing dobutamine

Details Stabilized pharmaceutical compositions containing dobutamine Stabilized pharmaceutical compositions containing dobutamine

1998-04-24

2000-01-25

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514474, A61K 31135

Patent

active

06017966&

ABSTRACT:
The present invention concerns stable injectable pharmaceutical compositions comprising dobutamine and ascorbic acid, or a salt thereof, and processes to prepare such compositions.

REFERENCES:
patent: 3808317 (1974-04-01), Hecht et al.
patent: 3966905 (1976-06-01), Nite
Bishara et al., Dobutamine Hydrochloride, Analytical Profiles of Drug Substances, vol. 8, pp 139-158 (1979).
Springer, et al., Stabiliation of eye drops containg adrenaline, ACTA FAC. PHARM. UNIV., vol. 36 pp. 173-191 (1981).
Kirshenbaum et al., Stability of Dobutamine Hydrochloride in selected large volume parenterals, AM. J.
HOSP. PHARM., vol. 39, No. 11, pp. 1923-1925 (1982).
Thoma K. et al., Stabilization of Adrenaline Solutions. 2. Report on the Stability fo Adrenaline Solutions, PHARMACT. Helv. vol. 61, No. 2, pp. 34-41 ( 1986).
Sucker H et al., Pharmaeutishche Technologie, THIEME VERLAG, P 215, TABLE 518 "1991 ".

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