Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1996-05-31
1998-09-08
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
514168, A61K 3159
Patent
active
058045732
ABSTRACT:
Pharmaceutically active derivatives of vitamin D.sub.2 and vitamin D.sub.3 in a solid state composition are stabilized by the presence of effective amounts of pharmaceutically acceptable antioxidant and polyoxyalkyl stabilizer. Specified antioxidants are butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), vitamin E, propyl gallate, .beta.-carotene and ascorbic acid, while specified stabilizers are polyethyleneglycols, polyethyleneglycol ethers, polyethyleneglycol esters, polyoxyethylated castor oil, polyoxyethylated hydrogenated castor oil, polyoxyethylated sorbitan fatty acid esters and polyoxyethylated glycerol fatty acid esters. Suitable proportions of these ingredients by weight lie within the ranges 0.00003 to 0.8 vitamin D.sub.2 or D.sub.3 derivative: 0.01 to 0.1 antioxidant: 0.03 to 30 polyoxyalkyl stabilizer. Compared with similar non-stabilized compositions, the inventive compositions are particularly stable at elevated temperatures and/or humidities.
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patent: 3932634 (1976-01-01), Kardys
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patent: 4928610 (1990-05-01), Meier et al.
patent: 4929610 (1990-05-01), Meier et al.
Dr. Herbert P. Fiedler, "Dictionary for Pharmaceutical Cosmetical and Associated Fields", 3rd, Revised and Supplemental Edition 1989.
Derwent Publication Ltd., Dec. 1991 re JP-A 3 27999 324.
Badio Barbara
Robinson Allen J.
Teva Pharmaceutical Industries Ltd.
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