Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1987-02-13
1991-09-03
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424495, 424683, 424686, 424692, 514394, 514395, 514925, 514927, A61K 930, A61K 916, A61K 3312, A61K 3310
Patent
active
050453211
ABSTRACT:
The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylaklyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt of magnesium and/or a basic inorganic salt of calcium, is physically stable.
REFERENCES:
patent: 4137325 (1979-01-01), Sellstedt et al.
patent: 4255431 (1981-03-01), Junggren et al.
patent: 4666919 (1987-05-01), Vend et al.
patent: 4686230 (1987-08-01), Rainer et al.
patent: 4689333 (1987-08-01), Nohara et al.
Journal of the Chemical Society, Chemical Communications, 125-127 (1986) (translation provided).
Hydroxypropyl Methylcellulose, TC-5, published by Shin-Etsu Chemical in 1975 and 1978 (translation provided).
In Up-to-Date Pharmaceutical Technology Series "No. 1", (1969), Coating of Drugs, pp. 246, 247 and 250 (translation provided).
European Search Report corresponding to European Application 87 30 1244.
Rote Liste, 1985 Ref. No. 59152.
E. Schroder et al., "Arzneimittelchemie II", vol. 2, 1976, pp. 307-308.
Central Patents Index, "Stabilization of Preparations Containing Ampicillin and Dicloxacillin/Cephalexin by Addition of Nontherapeutic Levels of an Antacid", JA-086965 (May 9, 1975), Derwent Publications Ltd., London, England (Mar. 2, 1976).
Handbook of Nonprescription Drugs, Fifth Ed. Pub. 1977, American Pharm. Assoc., pp. 7-10.
Hirai Shin-ichiro
Makino Tadashi
Tabata Tetsuro
Takeda Chemical Industries Ltd.
Waddell Frederick E.
Weddington Kevin E.
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