Stabilized pharmaceutical composition

Details Stabilized pharmaceutical composition Stabilized pharmaceutical composition

1993-09-10

1995-07-18

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424495, 424683, 424686, 424692, 514394, 514395, 514925, 514927, A61K 930, A61K 3312, A61K 3310, A61K 3308

Patent

active

054339596

ABSTRACT:
The pharmaceutical composition of the invention, which comprises a benzimidazole compound of the formula ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, cyano, carboxy, carboalkoxy, carboalkoxyalkyl, carbamoyl, carbamoylalkyl, hydroxy, alkoxy, hydroxyalkyl, trifluoromethyl, acyl, carbamoyloxy, nitro, acyloxy, aryl, aryloxy, alkylthio or alkylsulfinyl, R.sup.2 is hydrogen, alkyl, acyl, carboalkoxy, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, alkylcarbonylmethyl, alkoxycarbonylmethyl or alkylsulfonyl, R.sup.3 and R.sup.5 are the same or different and each is hydrogen, alkyl, alkoxy or alkoxyalkoxy, R.sup.4 is hydrogen, alkyl, alkoxy which may optionally be fluorinated, or alkoxyalkoxy, and m is an integer of 0 through 4, and a basic inorganic salt stabilizing agent, is physically stable. Magnesium and calcium basic inorganic salt stabilizing agents are particularly useful.

REFERENCES:
patent: 4137325 (1979-01-01), Sellstedt et al.
patent: 4255431 (1981-03-01), Junggren et al.
patent: 4563455 (1986-01-01), Ueda et al.
patent: 4634710 (1987-01-01), Fischli et al.
patent: 4666919 (1987-05-01), Ueno et al.
patent: 4686230 (1987-08-01), Rainer et al.
patent: 4689333 (1987-08-01), Nohara et al.
patent: 4767769 (1988-08-01), Hockley et al.
patent: 4786505 (1988-11-01), Lovgren et al.
patent: 4824856 (1989-04-01), Okabe et al.
patent: 4853230 (1989-08-01), Lovgren et al.
Malmqvist et al., "Studies on Direct Compression of Tablets," Acta Pharm. Suec., vol. 21, pp. 9-20, 1984.
Brandstrom et al., "Chemical Reactions of Omeprazole and Omeprazole Analogues", Acta Chemica Scandinavica, vol. 43, 1989, pp. 536-548.
Crooks et al., "Ordered Mixing in Direct Compression of Tablets", Powder Technology, vol. 14, 1976, pp. 161-167.
Westerberg, "Studies on Ordered Mixtures for Fast Release and Dissolution of Drugs With Low Aqueous Solubility," Department of Pharmaceutics, Uppsala University, 1992, pp. 11/12.
Benjamin et al., "Stabilization of Sulconazole Nitrate in a Topical Powder Formulation", International Journal of Pharmaceutics, vol. 14, 1983, pp. 209-221.
Hersey, "Ordered Mixing: A New Concept in Powder Mixing Practice", Powder Technology, vol. 11 (1975), pp. 41-44.
"Seizai-gaku", pp. 115/116, Ed. by Yoshinobu Nakai et al., pub. by Nanzando.
Hersey, "Preparation and Properties of Ordered Mixtures", Australian Journal of Pharmaceutical Sciences, Feb. 1977, vol. 6, No. 1, pp. 29-32.
Pilbrant et al., "Development of an Oral Formulation Omeprazole", pp. 113-120 (1983).
The United States Pharmacopeia, 1985, pp. 1277/1278.
Shotton et al., "Studies on Mixing Cohesive Powders", Science Communications, J. Pharm. Pharmac., 1971, vol. 23, Suppl. 261S, pp. 260-261.
Central Patents Index, "Stabilization of Preparations Containing Ampicillin and Dicloxacillin/Cephalexin . . . ", JA-086965, May 9, 1975, Derwent Publications Ltd., London, England (Mar. 2, 1976).
European Search Report corresponding to European Application 87 30 1244 (1987).
Rote Liste, 1985 Ref. No. 59152.
E. Schroder et al., "Arneimittelchemie II", vol. 2, 1976, pp. 307-308.
Handbook of Nonprescription Drugs, Fifth Ed., Pub. 1977, American Pharm. Assoc., pp. 7-10.
Journal of the Chemical Society, Chemical Communications, pp. 125-127 (1986).
Hydroxypropyl Methylcellulose, TC-5, published by Shin-Etsu Chemical in 1978 and 1978.
In Up-to-Date Pharmaceutical Technology Series "No. 1", (1969), Coating of Drugs, pp. 246, 247 and 250.

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