Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1994-08-25
1996-07-30
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514769, 514772, A61K 31135
Patent
active
055412319
ABSTRACT:
This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
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Steven M. Walters; Influence of pH on Hydrolytic Decomposition of Diethylopropion Hydrochloride: Stability Studies on Drug Substance and Tablets Using High-Performance Liquid Ohromatography Journ. of Pharm. Sciences; vol. 69; No. 10; Oct. 1980; pp. 1206-1209.
Kalidindi Sanvasi R.
Ruff Michael D.
Sutton, Jr. Joel E.
Brown Donald
Glaxo Wellcome Inc.
Neuner George W.
Rose Shep K.
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