Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing
Patent
1997-01-22
1999-07-13
Pak, John
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
424724, 514 63, 514970, A61K 31695, A61K 3300, A01N 5510
Patent
active
059223600
DESCRIPTION:
BRIEF SUMMARY
Silicon is an essential trace element for plants, animals and humans. In a watery environment silicon is initially present as ortho silicic acid which is quickly converted by polycondensation to polysilicic acid, which transposes into a colloidal solution and gels. Ultimately, insoluble silicates are formed.
In the same way as carbonic acid for compounds comprising carbon, ortho silicic acid is the most important metabolite for organic silicon compounds. Water glass (sodium ortho silicate) is the usual source of ortho silicic acid, which however hydrolyses after oral administration to mammals and forms insoluble and non-absorbable gels through polycondensation.
Organic silicon compounds such as alcohol esters, such as ethyl ortho silicate and glycol ortho silicate, cannot be used in biological systems because of the poor solubility and the low resistance to hydrolysis, but above all because of the unacceptable toxicity.
There therefore exists a need for a silicon-comprising preparation not possessing the above stated drawbacks, because silicon has a positive biological effect on nails, hair, skin, teeth, collagen, connective tissue, bones, encourages cell generation, stimulates the immune system against infections and toxins and inhibits degenerative (ageing)-processes.
The present invention is based on the insight that if ortho silicic acid is formed in the presence of a stabilizing agent, polycondensation is inhibited and even avoided and, furthermore organic silicon compounds substantially do not occur.
A first aspect of the present invention therefore relates to a preparation comprising ortho silicic acid which is stabilized with a stabilizing agent and is substantially free of organic silicon compounds.
A second aspect of the present invention relates to a method for preparing a preparation as according to claims 1-7, which comprises of: stabilizing agent; and
A third aspect of the present invention relates to a biological preparation containing a preparation according to claims 1-7, and/or a preparation prepared according to claims 8-13, and a pharmacologically acceptable diluent.
The biological preparation according to the invention is can be used for: sinusitis and ulcers. problems, gynaecology (fibroids, polycystic adenopathy); and the lymphatic system.
The stabilization using a stabilizing agent preferably takes place with stabilizing agents containing a nitrogen atom with a free electron pair which forms a complex with the silanol groups of the ortho silicic acid. Quaternary ammonium compounds are preferably used, for instance tetra-alkyl compounds, wherein each alkyl group contains for instance 1-5 carbon atoms, in particular methyl and ethyl groups. Very highly recommended are trialkylhydroxyalkyl compounds, wherein the hydroxy group is preferably methanol or ethanol. Choline has been found very suitable, which is further recommended in that it provides the option of the stabilizing agent also forming the solution for the ortho silicic acid, and an inert solvent can therefore be omitted.
Another or additional type of stabilizing agent is an amino acid, such as proline and serine. Serine enhances uptake in the stomach and gives additional stability.
Starting point for the preparation of the ortho silicic acid-comprising preparation is a solution containing the stabilizing agent, wherein an inert solvent can be used. Incorporated in -This solution is an inorganic silicon compound which hydrolysis under the influence of water to ortho silicic acid, which is immediately stabilized by the stabilizing agent that is present. The solution containing the stabilizing agent can initiate the hydrolysis immediately after addition of the inorganic silicon compound. Usually recommended is a solution containing a stabilizing agent in which no hydrolysis can take place until after the addition of a hydrolyzing agent, such as water.
If choline is used as stabilizing agent it can be converted to choline hydrochloride using dry hydrochloric acid. In this liquid stabilizing agent can be incorporated the inorganic
REFERENCES:
patent: 4466958 (1984-08-01), Morrison
patent: 4487712 (1984-12-01), Wilson et al.
`Gmelins Handbuch der Anorganischen Chemie Silicium Part B`, 1959 Verlag Chemie GmbH.
P. Pascal `Nouveau Traite de Chimie Minerale Paul Pascal Part VIII 2nd volume Silicium`, 1965, Masson and CY, Paris, FR.
Holleman-Wiberg `Lehrbuch der Anorganischen Chemie`, 1976, Verlag de Gruyter, Berlin, DE.
Bio Pharma Sciences B.V.
Pak John
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