Stabilized microbubble compositions for ultrasound

Details Stabilized microbubble compositions for ultrasound Stabilized microbubble compositions for ultrasound

1994-08-01

1997-02-25

Burn, Brian M.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

A61K 4900

Patent

active

056056737

ABSTRACT:
A microbubble preparation formed of a plurality of microbubbles comprising a first gas and a second gas surrounded by a membrane such as a surfactant, wherein the first gas and the second gas are present in a molar ratio of from about 1:100 to about 1000:1, and wherein the first gas has a vapor pressure of at least about (760-x) mm Hg at 37.degree. C., where x is the vapor pressure of the second gas at 37.degree. C., and wherein the vapor pressure of each of the first and second gases is greater than about 75 mm Hg at 37.degree. C.; also disclosed are methods for preparing microbubble compositions, including compositions that rapidly shrink from a first average diameter to a second average diameter less than about 75% of the first average diameter and are stabilized at the second average diameter; methods and kits for preparing microbubbles; and methods for using such microbubbles as contrast agents.

REFERENCES:
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 5186922 (1993-02-01), Shell et al.
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5305757 (1994-04-01), Unger et al.
patent: 5310540 (1994-05-01), Giddey et al.
patent: 5315997 (1994-05-01), Widder et al.
patent: 5315998 (1994-05-01), Tachibana et al.
patent: 5333613 (1994-08-01), Tickner et al.
patent: 5334381 (1994-08-01), Unger
patent: 5348016 (1994-09-01), Unger et al.
patent: 5352435 (1994-10-01), Unger
patent: 5352436 (1994-10-01), Wheatley et al.
patent: 5376380 (1994-12-01), Kikuchi et al.
patent: 5380519 (1995-01-01), Schneider et al.
patent: 5393524 (1995-02-01), Quay
patent: 5558856 (1996-09-01), Klaveness et al.
patent: 5558857 (1996-09-01), Klaveness et al.
Kitagawa, et al. Biological Abstracts 63:6392 (1977).
Keough, et al. Biological Abstracts 105308 (1986).
Matsuda, et al. "Contrast Echocardiography of the Left Heart by Intravenous Injection of Perfluorochemical Emulsion" J. of Cardiography 13(4): 1021-1028 (1983).
Sunamoto, et al. "Liposomal Membranes" J. Biochem. 88:1219-1226 (1980).
N. de Jong, et al. "Principles and Recent Developments in Ultrasound Contrast Agents", Ultrasonics. 29:324-330, 1991.

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