Stabilized medicinal aerosol solution formulations

Details Stabilized medicinal aerosol solution formulations Stabilized medicinal aerosol solution formulations

1995-06-07

1997-10-14

Bawa, Raj

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 46, A61K 912

Patent

active

056769300

ABSTRACT:
Stabilized medicinal aerosol solution formulations comprising medicaments that degrade or decompose by interaction with solvents or water, an HFC propellant, a cosolvent and an acid are described. Further, specific medicinal aerosol solution formulations comprising ipratropium bromide or fenoterol, ethyl alcohol, 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane, and either an inorganic acid or an organic acid are described. The acids are present in amounts sufficient to reduce the degradation of the medicaments to acceptable levels.

REFERENCES:
patent: 5118494 (1992-06-01), Schultz et al.
patent: 5190029 (1993-03-01), Byron et al.
patent: 5225183 (1993-07-01), Purewal et al.
patent: 5439670 (1995-08-01), Purewal et al.
patent: 5605674 (1997-02-01), Purewal et al.

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