Stabilized liquid anti-RSV antibody formulations

Details Stabilized liquid anti-RSV antibody formulations Stabilized liquid anti-RSV antibody formulations

2011-08-30

2011-08-30

Navarro, Albert (Department: 1645)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

C424S141100, C424S147100, C424S159100

Reexamination Certificate

active

08007793

ABSTRACT:
The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and/or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.

REFERENCES:
patent: 4360457 (1982-11-01), Ono et al.
patent: 4374763 (1983-02-01), Takagi
patent: 4517304 (1985-05-01), Stott et al.
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4597966 (1986-07-01), Zolton et al.
patent: 4659563 (1987-04-01), Dobkin
patent: 4703039 (1987-10-01), Hawiger et al.
patent: 4717766 (1988-01-01), Dobkin
patent: 4760026 (1988-07-01), Lennox et al.
patent: 4800078 (1989-01-01), Prince et al.
patent: 4853326 (1989-08-01), Quash et al.
patent: 4917893 (1990-04-01), Okada et al.
patent: 4992419 (1991-02-01), Woog et al.
patent: 5071758 (1991-12-01), Stott et al.
patent: 5128326 (1992-07-01), Balazs et al.
patent: 5137804 (1992-08-01), Greene et al.
patent: 5149650 (1992-09-01), Wertz et al.
patent: 5183657 (1993-02-01), Buurman
patent: 5194595 (1993-03-01), Wathen
patent: 5219996 (1993-06-01), Bodmer et al.
patent: 5223254 (1993-06-01), Paradiso et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5240694 (1993-08-01), Gwaltney, Jr.
patent: 5271927 (1993-12-01), Parker et al.
patent: 5279935 (1994-01-01), Nycz
patent: 5288630 (1994-02-01), Wathen
patent: 5290540 (1994-03-01), Prince et al.
patent: 5332567 (1994-07-01), Goldenberg
patent: 5332805 (1994-07-01), Carey et al.
patent: 5340926 (1994-08-01), Lowe et al.
patent: 5354554 (1994-10-01), Rhind
patent: 5391478 (1995-02-01), Greene et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5411749 (1995-05-01), Mayo et al.
patent: 5412077 (1995-05-01), Siber et al.
patent: 5418136 (1995-05-01), Miller et al.
patent: 5422097 (1995-06-01), Gwaltney, Jr.
patent: 5424189 (1995-06-01), Oberst et al.
patent: 5468606 (1995-11-01), Bogart et al.
patent: 5470736 (1995-11-01), Verma et al.
patent: 5476997 (1995-12-01), Kaneshima et al.
patent: 5484893 (1996-01-01), Parker et al.
patent: 5496703 (1996-03-01), Babish et al.
patent: 5506209 (1996-04-01), Mukerji et al.
patent: 5518725 (1996-05-01), Daynes et al.
patent: 5530102 (1996-06-01), Gristina et al.
patent: 5534411 (1996-07-01), Weltzin
patent: 5538733 (1996-07-01), Emery et al.
patent: 5538952 (1996-07-01), Mukerji et al.
patent: 5571698 (1996-11-01), Ladner et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5608038 (1997-03-01), Eibl et al.
patent: 5624821 (1997-04-01), Winter
patent: 5648260 (1997-07-01), Winter
patent: 5667988 (1997-09-01), Barbas et al.
patent: 5679377 (1997-10-01), Bernstein et al.
patent: 5693762 (1997-12-01), Queen et al.
patent: 5739277 (1998-04-01), Presta et al.
patent: 5747035 (1998-05-01), Presta et al.
patent: 5762905 (1998-06-01), Burton et al.
patent: 5811524 (1998-09-01), Brams et al.
patent: 5824307 (1998-10-01), Johnson et al.
patent: 5840298 (1998-11-01), Brams et al.
patent: 5855913 (1999-01-01), Hanes et al.
patent: 5866125 (1999-02-01), Brams et al.
patent: 5869046 (1999-02-01), Presta et al.
patent: 5871736 (1999-02-01), Bruegger et al.
patent: 5874064 (1999-02-01), Edwards et al.
patent: 5912015 (1999-06-01), Bernstein et al.
patent: 5916597 (1999-06-01), Lee et al.
patent: 5929212 (1999-07-01), Jolliffe et al.
patent: 5934272 (1999-08-01), Lloyd et al.
patent: 5939068 (1999-08-01), Brams et al.
patent: 5955364 (1999-09-01), Brams et al.
patent: 5958765 (1999-09-01), Brams et al.
patent: 5961927 (1999-10-01), Isaacs et al.
patent: 5985309 (1999-11-01), Edwards et al.
patent: 5985320 (1999-11-01), Edwards et al.
patent: 5989463 (1999-11-01), Tracy et al.
patent: 6019968 (2000-02-01), Platz et al.
patent: 6096551 (2000-08-01), Barbas et al.
patent: 6117980 (2000-09-01), Gonzalez et al.
patent: 6121022 (2000-09-01), Presta
patent: 6165745 (2000-12-01), Ward et al.
patent: 6171586 (2001-01-01), Lam et al.
patent: 6194551 (2001-02-01), Idusogie
patent: 6277375 (2001-08-01), Ward
patent: 6413771 (2002-07-01), Brams et al.
patent: 6519948 (2003-02-01), Zorn
patent: 6528624 (2003-03-01), Idusogie
patent: 6537809 (2003-03-01), Brams
patent: 6538124 (2003-03-01), Idusogie
patent: 6565849 (2003-05-01), Koenig
patent: 6565888 (2003-05-01), Tracy et al.
patent: 6572856 (2003-06-01), Taylor et al.
patent: 6586008 (2003-07-01), Batycky et al.
patent: 6656467 (2003-12-01), Young et al.
patent: 6685942 (2004-02-01), Burton et al.
patent: 6737056 (2004-05-01), Presta
patent: 6818216 (2004-11-01), Young et al.
patent: 6855493 (2005-02-01), Young et al.
patent: 7083784 (2006-08-01), Dall'Acqua
patent: 7132100 (2006-11-01), Oliver et al.
patent: 7179900 (2007-02-01), Young et al.
patent: 7208162 (2007-04-01), Prince et al.
patent: 7229619 (2007-06-01), Young et al.
patent: 7279182 (2007-10-01), Lipp et al.
patent: 7294336 (2007-11-01), Oliver et al.
patent: 7323172 (2008-01-01), Young et al.
patent: 7416726 (2008-08-01), Ravetch
patent: 7425618 (2008-09-01), Oliver et al.
patent: 7553489 (2009-06-01), Young et al.
patent: 7635568 (2009-12-01), Young et al.
patent: 7658921 (2010-02-01), Dall'acqua et al.
patent: 7670600 (2010-03-01), Dall'Acqua et al.
patent: 7700735 (2010-04-01), Young et al.
patent: 7704497 (2010-04-01), Dall'Acqua et al.
patent: 7740851 (2010-06-01), Young
patent: 7785592 (2010-08-01), Oliver
patent: 7847082 (2010-12-01), Young et al.
patent: 2001/0034062 (2001-10-01), Koenig
patent: 2002/0004046 (2002-01-01), Johnson
patent: 2002/0018780 (2002-02-01), Koenig et al.
patent: 2002/0102257 (2002-08-01), Johnson
patent: 2003/0091584 (2003-05-01), Young et al.
patent: 2004/0002587 (2004-01-01), Watkins
patent: 2004/0005323 (2004-01-01), Brams et al.
patent: 2004/0005324 (2004-01-01), Pilkington et al.
patent: 2004/0018200 (2004-01-01), Oliver et al.
patent: 2004/0018243 (2004-01-01), Basu et al.
patent: 2004/0038878 (2004-02-01), Tanikawa et al.
patent: 2004/0076631 (2004-04-01), Brams et al.
patent: 2004/0131609 (2004-07-01), Young et al.
patent: 2005/0196749 (2005-09-01), Young et al.
patent: 2006/0099220 (2006-05-01), Tous et al.
patent: 2006/0115485 (2006-06-01), Losonsky et al.
patent: 2007/0048332 (2007-03-01), Oliver et al.
patent: 2008/0286270 (2008-11-01), Oliver et al.
patent: 2009/0175883 (2009-07-01), Oliver et al.
patent: 2010/0028948 (2010-02-01), Young et al.
patent: 2010/0098708 (2010-04-01), Losonsky et al.
patent: 2010/0189718 (2010-07-01), Dall'acqua
patent: 2010/0239574 (2010-09-01), Young et al.
patent: 2010/0266614 (2010-10-01), Young et al.
patent: 713113 (1999-11-01), None
patent: 2002219944 (2008-02-01), None
patent: 2197684 (1996-02-01), None
patent: 0 025 321 (1981-03-01), None
patent: 0 025 719 (1981-03-01), None
patent: 0 327 378 (1989-08-01), None
patent: 0 368 684 (1990-05-01), None
patent: 0 413 622 (1991-02-01), None
patent: 0 420 649 (1991-04-01), None
patent: 0671927 (1995-09-01), None
patent: 0682040 (1995-11-01), None
patent: 0451216 (1996-01-01), None
patent: 0699756 (1996-03-01), None
patent: 1259547 (2001-09-01), None
patent: 1265928 (2002-12-01), None
patent: 1 314 437 (2003-05-01), None
patent: 1336410 (2003-08-01), None
patent: 2758331 (1998-07-01), None
patent: 1268646 (1989-10-01), None
patent: WO 89/07142 (1989-08-01), None
patent: WO 90/07861 (1990-07-01), None
patent: WO 91/04743 (1991-04-01), None
patent: WO 91/05548 (1991-05-01), None
patent: WO 91/14438 (1991-10-01), None
patent: WO 92/05274 (1992-04-01), None
patent: WO 92/19244 (1992-11-01), None
patent: WO 93/05796 (1993-04-01), None
patent:

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