Stabilized liposome/amphotericin composition and method

Details Stabilized liposome/amphotericin composition and method Stabilized liposome/amphotericin composition and method

1985-09-27

1988-08-23

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 43, 264 46, 436829, 514 31, A61K 942, A61J 500

Patent

active

047660465

ABSTRACT:
A dehydrated liposome/amphotericin B composition which, upon addition of an aqueous medium, forms a suspension of liposomes (a) having a predetermined size distribution in size range less than about 1 micron, and (b) containing at least about 1 mole percent amphotericin B. The composition is prepared by forming a suspension of heterogeneous size amphotericin B liposomes in an aqueous solution containing at least about 0.5% of a membrane-stabilizing agent. The suspension is sized--for example, by extrusion through a small-pore polycarbonate membrane--to produce liposomes having the selected size distribution, and dehydrated.

REFERENCES:
patent: 4411894 (1983-10-01), Shrank et al.
patent: 4529561 (1985-07-01), Hunt et al.
Mehta et al., Bichimica et Biophysica Acta 770: 230-234 (1984).
Tremblay et al., Antimicrobial Agents and Chemotherapy, 26(2): 170-173 (1984).
Remington, Pharmaceutical Sciences, Mack Pub., Easton, 1980, Chapter 78.
Olson et al., Biochimica et Biophysica Acta, 557: 9-23 (1979).
Crowe et al., Biochimica et Biophysica Acta, 769: 141-150 (1984).
Lopez-Berestein et al., J. Infec. Dis., 151(4): 704-710 (1985).
Graybill et al., J. Infec. Dis., 145(5): 748-752 (1982).
Lopez-Berestein et al., J. Infec. Dis., 150(2): 278-283 (1984).

Affiliated with

Also associated with

Rating

Stabilized liposome/amphotericin composition and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilized liposome/amphotericin composition and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized liposome/amphotericin composition and method will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-835475