Stabilized liposome/amphotercin B composition and method

Details Stabilized liposome/amphotercin B composition and method Stabilized liposome/amphotercin B composition and method

1990-12-14

1993-01-19

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424450, A61K 3170, A61K 3722

Patent

active

051807130

ABSTRACT:
A method of administering a liposome/amphotericin B composition having a predetermined size distribution in 0.2-0.5 micron size range. The method includes preparing a suspension of heterogeneously sized amphotericin B liposomes in an aqueous solution containing at least about 0.5% w/v of membrane-stabilizing agent. After sizing to the desired size distribution, and before the liposome sizes change substantially, the suspension is lyophilized for storage. After reconstituting the lyophilized material, the resulting suspension is administered before a substantial size changes in the liposomes occur.

REFERENCES:
patent: 4766046 (1988-08-01), Abra et al.
Tremblay "Efficacy of Liposome-Intercalated Amphotericin B in the Treatment of Systemic Candidiasis in Mice Antimicrobial Agents and Chemotherapy" 26(2) pp. 170-173 (1984).

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