Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1996-03-12
1998-11-17
Webman, Edward J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424484, 428245, 428260, 428262, 428289, 4283044, 604304, 604305, A61K 970, A61M 3700, B32B 300
Patent
active
058372814
ABSTRACT:
An interface is formed by incorporating (1) a mixture comprising a water-soluble protein and a drug into a matrix, or preferably (2) a mixture comprising a water-soluble protein and a drug to a porous matrix coated with a cationic surfactant or other ionic surfactant. The coating amount of the ionic surfactant is about 0.1 to 50 .mu.g, and the content of the water-soluble protein is about 0.1 to 1,500 .mu.g, each per 1 cm.sup.2 of the matrix. The water-soluble protein includes an albumin and the drug includes a physiologically active peptide or protein, for example. The use of the stabilized interface inhibits decrease of the drug retaining amount, and insures an effective transdermal drug delivery with a high repeatability and accuracy.
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Patent Abstracts of Japan, vol. 018, No. 222 (C-1193) of JP-A-06 016535.
Iga Katsumi
Kyo Emi
Misaki Masafumi
Okabe Keiichiro
Advance Co., Ltd.
Takeda Chemical Industries Ltd.
Teikoku Hormone Mfg. Co. Ltd.
Webman Edward J.
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