Stabilized insulin formulations

Details Stabilized insulin formulations Stabilized insulin formulations

1987-11-13

1989-06-13

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 514494, A61K 3726

Patent

active

048393410

ABSTRACT:
This invention provides an insulin formulation stabilized against aggregation containing a hydroxybenzene and a polyethylene glycol-polypropylene glycol polymer of the formula ##STR1## having an average molecular weight of about 8350 and in which the average number of ethyleneoxy units per molecule, designated by the sum of a and c, is about 150, and the average number of propyleneoxy units per molecule, designated as b, is about 30.

REFERENCES:
patent: 4129560 (1978-12-01), Zoltobrocki
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The Merck Index, 9th ed. Merck & Co Inc., Rahway, N.J., 1976, Entry No. 7342, p. 983.
USAN and the USP Dictionary of Drug Names, Ed. by Mary C. Griffiths, U.S. Pharmacopeil Convention, Inc. Rockville, Md., p. 260, from Jun. 15, 1961, Through Jun. 15, 1979.
Wu et al., Biochimics et Biophysica Acta, 667, 285-293 (1981).
Swim, H. E. and Parker, R. F. Effect of Pluronic F68 on Growth of Fibroblasta in Suspension on Rotary Shaker. Proc. Soc. Exp. Bio. Med. 103, 252 (1960).
Lougheed, D., Albisser, A. M., Chow, J. C. and Clement, J. R. Physical Stability of Insulin Formulations. Diabetes 32, 424 (1983).
Henry, M., McMullen, J. K., Grant, A. P., Tindall, C. E. A Solution for Insulin Aggregation. Irish J. Med. Sci. 230 (1982).
Thurow et al., Diabetoligia 27, 212-218 (1984).

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