Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1983-12-02
1988-09-27
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424418, 424494, A01N 2528, A01N 2534, A61K 950
Patent
active
047740906
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The invention relates to a stabilized insecticidal composition comprising isopropyl (2E,4E)-3,7,11-trimethyl-11-methoxy-2,4-dodecadienoate, said composition being used in admixture with cattle feed. The composition of the invention is suitable for inhibiting the propagation of flies in the cattle excrement.
BACKGROUND ART
It is known that isopropyl (2E,4E)-3,7,11-trimethyl-11-methoxy-2,4-dodecadienoate (referred to furtheron as methoprene) exhibits useful insecticidal effects (U.S. Pat. No. 3,904,662).
According to U.S. Pat. No. 3,912,815 polymeric capsules comprising methoprene can be used for the extermination of undeveloped insects living on or under the surface of soil.
According to J. Eco. Entomol. 67, 69-70 (1974) methoprene as a juvenile hormone estergase inhibiting substance when applied onto the larvae of different Diptera species is capable of inhibiting the energence of the imagos from the nymphs. The effective concentration of methoprene might vary depending on the larvae of the different species. According to in vitro tests 10 ppm of methoprene added to the dung completely inhibits the energence of imago from the nymphes formed from the larvae of the Musca autumnalis species. In the case of Musca domestica a concentration of 100 ppm resulted in an inhibition of 90%. A similar effect was observed on the larvae of Stomoxys calcitrans too, while methoprene proved to be the most effective against the larvae of Haematobia irritans. Due to its high activity and very low toxicity methopren can enter the excrement by feeding the methoprene to the animals. On oral administration the following activity was found against the most important fly species. 1099-1102 (1973),
According to hitherto applied practical methods cattle ingest methoprene either dissolved in the drinking water or admixed with the salt or proteine fodder. The drawback of consumption of the drinking water is that uniform concentration can only be ensured by using expensive specific equipment. The safest ingestion in the form of a solid nutriment consists of the addition of methoprene to mineral salt additives since said additives are more widespreadly used in cattle husbandry than other feed additives. At the same time said use encounters difficulties because as a result of chemical lability of methoprene the active ingredient content of said compositions decreases very rapidly, particularly when used for cattle grazing on pasture land, where the weather conditions--first of all sunshine--accelerate the chemical decomposition to a large extent. Thus, according to J. Eco. 67, 384-386 (1974) the active ingredient content of salt blocks comprising 0.9% of methoprene and stored in a store-house for 9 weeks decreases by 13-30%. According to J. Eco. Entomol. 71, 274-278 (1978) in a salt mixture stored under field conditions the average decrease of the active ingredient content within 10 days amounts to 26%.
DISCLOSURE OF INVENTION
The object of the invention is to provide a stabilized methoprene composition which overcomes the above disadvantages of the known formulations.
It has been found that the decomposition of methoprene can be slowed down by means of antioxidants and light-protecting agents. As antioxidant butyl hydroxy toluene can be used. The known light protecting agents are, however, unsuitable for use in the present invention for food hygienic reasons.
It has been surprisingly found that by using activated charcoal, which is harmless from a hygienical point of view, excellent results can be obtained.
The present invention is based on the recognition that by dissolving 1-15% by weight of butyl hydroxy toluene and suspending 5-40% by weight of activated charcoal in technical grade methoprene and transforming the suspension thus obtained into a powder having a grain size of 1-300 .mu.m by a suitable microencapsulating method, the triple protection--namely anti-oxidant effect, light-protecting effect and barrier effect of the wall of the microcapsules--ensures suitable stability of methoprene.
According to the p
REFERENCES:
patent: 3912815 (1975-10-01), Henrick et al.
Harris et al. "Horn Flies and Stable Flies" Free Choice Feeding of Methopreve Mineral Blocks to Cattle for Control J. Eco. Ent 67:3843810.
CA. 99(4):28007a "Cellulose Acetate Phthalate Microencapsulation" Felcete et al.
Fekete Pal
Kelemen Jozsef
Magyar Karoly
Mayer nee Almasi Anna
Toth Katalin
Dubno Herbert
Egyt Gyogyszervegyeszeti Gyar
Myers Jonathan
Robinson Allen J.
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