Stabilized immunoglobulins

Details Stabilized immunoglobulins Stabilized immunoglobulins

2004-01-05

2009-10-27

Zeman, Robert A (Department: 1645)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

C424S130100

Reexamination Certificate

active

07608260

ABSTRACT:
The present invention provides stabilized immunoglobulin molecules that have increased storage stability and/or in vivo half-lives due to the mutation of one or more amino acids that would otherwise render the immunoglobulin molecules susceptible to degradation. In a preferred embodiment, the stabilized immunoglobulins of the invention have mutations at the heavy chain constant domain hinge region. Such stabilized immunoglobulin molecules, i.e., immunoglobulin molecules with increased storage stability have one or more of the following advantages they are more readily transported and/storable for longer periods and/or less stringent conditions than non-stabilized counterparts; that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such stabilized molecules.

REFERENCES:
Bowie et al. (Science 1990, vol. 247, pp. 1306-1310.
Xiang et al., Structural effect of recombinant monoclonal antibody on hinge region peptide bond hydrolysis, Journal of Chromatography B, 858 (2007), pp. 254-262.

Affiliated with

Also associated with

Rating

Stabilized immunoglobulins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilized immunoglobulins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized immunoglobulins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4140065