Stabilized human tissue plasminogen activator compositions

Details Stabilized human tissue plasminogen activator compositions Stabilized human tissue plasminogen activator compositions

1990-03-12

1991-07-23

Rollins, John W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

514561, 514970, A61K 37547, A61K 31195

Patent

active

050342258

ABSTRACT:
Disclosed are novel, stable pharmaceutically acceptable compositions containing human tissue plasminogen activator, featuring, for example, an argininium ion containing buffer as a component. Also disclosed are associated means and methods for preparing and using such compositions in various forms.

REFERENCES:
patent: 4505893 (1985-03-01), Mori et al.
patent: 4552760 (1985-11-01), Murakami et al.
patent: 4777043 (1988-10-01), Bennett et al.
patent: 4857320 (1989-08-01), Wittwer
patent: 4908205 (1990-03-01), Bennett et al.
Binder, Bernd R., et al., The Journal of Biological Chemistry 254:1998-2003 (1978).
Aoki, Nobuo J. Biological Chemistry 75:731-741 (1974).

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