Stabilized human monoclonal antibody preparation

Details Stabilized human monoclonal antibody preparation Stabilized human monoclonal antibody preparation

1997-11-14

2000-12-26

Saunders, David

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241421, 4241771, 5303888, 53038815, 5303905, C07K 1630, A61K 39395

Patent

active

061654671

ABSTRACT:
A stabilized human monoclonal antibody preparation containing 1 to 20 mg of D-mannitol per 1 mg of a human monoclonal antibody. This preparation is excellent in stability in a solution state, a freeze drying state and a freezing state, particularly stability against aggregation and precipitation of the human monoclonal antibody at the time of redissolution after freeze drying.

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