Stabilized hepatitis B e antigen suitable for immunoassays

Details Stabilized hepatitis B e antigen suitable for immunoassays Stabilized hepatitis B e antigen suitable for immunoassays

1994-06-06

1996-03-26

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 693, 436518, 436820, C12Q 170

Patent

active

055019480

ABSTRACT:
Methods and materials for producing hepatitis virus HBe antigenic proteins useful in immunoassays without the necessity of maintaining these proteins in denaturing environments are disclosed. Assay methods and materials utilizing these HBe proteins are also provided.

REFERENCES:
patent: 4563423 (1986-01-01), Murray et al.
patent: 4758507 (1988-07-01), Murray et al.
Slusarczyk et al., Association of hepatitis B e antigen (HBeAg) with the core of the hepatitis B virus (HBcAg). Liver 5:48-53 (1985).
MacKay et al., The conversion of hepatitis B core antigen synthesized in E. coli into e antigen. J. Med. Virol. 8:237-243 (1981).
Yoshizawa et al., Demonstration of hepatitis B e antigen in hepatitis B core particles obtained from the nucleus of hepatocytes infected with hepatitis B virus. J. Gen. Virol. 42:513-519 (1979).
Takahashi et al., Immunochemical structure of hepatitis B e antigen in the serum. J. Immunol. 130:2903-2907 (1983).
Ma et al., Effect of pre-core and portion of core sequence on the expression of HBcAg in E. coli. Laboratory of Molecular Genetics, Institute of Basic Medical Sciences, Beijing, P.R. China.
Spiezia et al., Re-examination and further characterization of a monoclonal antibody to hepatitis B e Antigen (anti-HBe). J. Virol. Methods 13:351-362 (1986).
Oellerich, "Enzyme-Immunoassay: A Review", J. Clin. Chem. Clin. Biochem., vol. 22, No. 12, pp. 895-904, 1984.

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