Stabilized galenic formulations comprising an acid labile benzim

Details Stabilized galenic formulations comprising an acid labile benzim Stabilized galenic formulations comprising an acid labile benzim

1995-04-27

1997-05-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424480, 424451, A61K 916, A61K 950

Patent

active

056268750

ABSTRACT:
New stable oral pharmaceutical formulations are prepared by covering an inert nucleus with a first layer containing an acid labile benzimidazole compound, a water soluble polymer and non-alkaline reacting pharmaceutical acceptable excipients, a second isolation layer containing a water soluble polymer, pharmaceutical acceptable excipients and a final enteric coating.

REFERENCES:
patent: 4150111 (1979-04-01), Warren
patent: 4287221 (1981-09-01), Tonedachi
patent: 4335099 (1982-06-01), Funakoshi
patent: 4377568 (1983-03-01), Chopra
patent: 4470980 (1984-09-01), Higuchi
patent: 5232706 (1993-08-01), Coll
patent: 5395611 (1995-03-01), Jimbow
Coating of Drugs, Up-to-Date Pharmaceutical Technology Series "No. 1", pp. 1 and 2, Jiji Printing Co., Ltd., Dec. 1, 1969.
"Hagers Handbook Der Pharmazeutischen Proxis", vol. 7A, p. 760 (1971 edition).
The United States Pharmacopeia, The National Formulary, p. 2313, 1994.

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