Stabilized formulations of gamma interferons

Details Stabilized formulations of gamma interferons Stabilized formulations of gamma interferons

1987-06-09

1990-01-23

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 854, A61K 4502

Patent

active

048957160

ABSTRACT:
This invention relates to compositions and methods useful for the stabilization of interferons. More particularly, this invention relates to the formulation of gamma interferons with lactobionic acid in an acetate/glycine buffer.

REFERENCES:
patent: 4252791 (1981-02-01), Grossberg et al.
patent: 4675183 (1987-06-01), Kato et al.
patent: 4714611 (1987-12-01), Yasaburgo et al.
Bonnem et al., J. Biol. Response Modifiers, vol. 6, pp. 275-301, 1987.
Sedmak et al., "Stabilization of Interferons", Texas Reports on Biology and Medicine, 35, pp. 198-204, (1977).
Sedmak et al., "Thermal and Vortical Stability", Human Interferon Production and Clinical Use, pp. 133-152, Plenam Press, (1978).
Sedmak et al., "Procedures for Stabilization of Interferons", Methods in Enzymology, 78, pp. 591-595, (1981).
Jameson et al., "Thermal Stability of Freeze Dried Mammalian Interferons", Cryobiology, 16, pp. 301-314, (1979).

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