Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form
Reexamination Certificate
2007-06-12
2007-06-12
Webman, Edward J. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
C424S423000, C514S784000, C514S788000
Reexamination Certificate
active
10465810
ABSTRACT:
The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the effects of an anesthetic agent, preferably a long-lasting local anesthetic agent administered in conjunction with an alpha adrenergic receptor agonist.
REFERENCES:
patent: 4508715 (1985-04-01), Booth et al.
patent: 4659714 (1987-04-01), Watt-Smith
patent: 4888344 (1989-12-01), Sunagawa et al.
patent: 4938970 (1990-07-01), Hustead et al.
patent: 5149320 (1992-09-01), Dhaliwal et al.
patent: 5192527 (1993-03-01), Abrahmsohn
patent: 5261903 (1993-11-01), Dhaliwal et al.
patent: 6001845 (1999-12-01), Estok
patent: 6025396 (2000-02-01), Kim et al.
patent: 6043224 (2000-03-01), Lee et al.
patent: 6106866 (2000-08-01), Ranney
patent: 6432401 (2002-08-01), Weber et al.
patent: 6872390 (2005-03-01), Weber et al.
patent: 2002/0183356 (2002-12-01), Weber et al.
patent: 2002/0183396 (2002-12-01), Weber et al.
patent: WO 01/85171 (2001-11-01), None
Ahn, J., and Pogrel, M.A., “The effects of 2% lidocaine with 1:100,000 epinephrine on pulpal and gingival blood flow,”Oral Surg. Oral Med. Oral. Pathol. Oral Radiol. Endod. 85:197-202, Mosby, Inc. (1998).
Alverez, D.J., and Rockwell, P.G., “Trigger Points: Diagnosis and Management,”Am. Fam. Physician65:653-660, American Academy of Family Physicians (Feb. 2002).
Bernstein, R.M., and Rassman, W.R., “Limiting epinephrine in large hair transplant sessions,”Hair Transplant Forum International10:39-42, New Hair Institute, Inc. (2000), accessed on Aug. 23, 2002 <http://www.800newhair.com/medical—publications/limiting—epinephrine.html>.
Hardy, S.J., and Agostini, D.E., “Accidental epinephrine auto-injector-induced digital ischemia reversed by phentolamine digital block,”J. Am. Osteopathic Assoc. 95:377-378, American Osteopathic Association (1995).
Heasman, P.A., and Jacobs, D.J., “A Clinical Investigation into the Incidence of Dry Socket,”Br. J. Oral Maxillofacial Surg. 22:115-122, Churchhill Livingstone (1984).
Maguire, W.M., et al., “Epinephrine-Induced Vasospasm Reversed by Phentolamine Digital Block,”Am. J. Emerg. Med. 8:46-47, (1990).
McGovern, S.J., “Treatment of accidental digital injection of adrenaline from an auto-injector device,”J. Accid. Emerg. Med. 14:379-380, BMJ Publishing Group (1997).
Medical Economics,Physicians' Desk Reference, Medical Economics Company, Inc., Montvale, NJ, pp. 3135-3137 (Nov. 2001).
Pimentel, L.A.S., and Goldenburg, R.C.D.S., “Local Injection of Hyaluronidase in Increasing Skin Flap Survival: An Experimental Study,”Revista da Sociedade Brasileira de Cirurgia Plastica14:49-55, Sociedade Brasileira de Cirurgia Plastica (1999).
Robertson, V.J., et al., “Quantitative and Qualitative Analysis of the Pressor Effects of Levonordefrin,”J. Cardiovasc. Pharmacol. 6:929-935, Raven Press (1984).
Swinyard, E.A., “Local Anesthetics,” inRemington's Pharmaceutical Sciences, Osol, A. et al., eds., Mack Publishing Co., Easton, PA, pp. 991-1003 (1980).
Medical Economics,Physicians' Desk Reference, Medical Economics Company, Inc., Montvale, NJ, pp. 464, 2668, 2669, 3135 and 3268 (Nov. 2001).
Wilson, C.O., and Gisvold, O., eds.,Textbook of Organic Medicinal and Pharmaceutical Chemistry, 2ndEdition, J.B. Lippincott Company, Philadelphia, PA, pp. 25-27 (1954).
International Search Report for International Application No. PCT/US03/19440, mailed Dec. 10, 2003, International Searching Authority, U.S.A.
Edwall, B., et al., “Neuropeptide Y (NPY) and sympathetic control of blood flow in oral mucosa and dental pulp in the cat,”Acta Physiol. Scand. 125:253-264, Blackwell Scientific Publications (1985).
Koss, M.C., “Differential neural activation of vascular α-adrenoceptors in oral tissues of cats,”Eur. J. Pharmacol. 440:53-59, Elsevier Science B.V. (Apr. 2002).
Crawford, R.A., et al., “The response of feline spinal pial arterioles to norepinephrine,”J. Neurosurg. 52:60-63, American Association of Neurological Surgeons (1990).
Chen Andrew X.
Knowles Julius
Weber Eckard
Novalar Pharmaceuticals, Inc.
Sterne Kessler Goldstein & Fox P.L.L.C.
Webman Edward J.
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