Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1990-07-03
1993-02-23
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
424477, 424482, 525 541, 530397, A61K 3736
Patent
active
051891484
ABSTRACT:
Disclosed are (1) a stabilized FGF protein composition which comprises an FGF protein and water-insoluble hydroxypropyl cellulose; (2) a method for preparing a stabilized FGF protein composition, which comprises admixing an FGF protein with a water-insoluble hydroxypropyl cellulose; and (3) a method for stabilizing an FGF protein which comprises admixing an FGF protein with a water-insoluble hydroxypropyl cellulose, whereby the stabilized FGF protein can be provided. The composition is obtained in a solid state which has improved stability.
REFERENCES:
patent: 4717717 (1988-01-01), Finkenaur
Journal of Cellular Physilosy, 128, 475 (1986).
Bioch. Biophys. Res. Commun. 151, 701 (1988).
Akiyama Yohko
Kitamori Nobuyuki
Yoshioka Minoru
Conlin David G.
Schain Howard E.
Takeda Chemical Industries, Inc.
Williams Gregory D.
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