Chemistry: molecular biology and microbiology – Vector – per se
Patent
1997-07-14
2000-05-02
Brusca, John S.
Chemistry: molecular biology and microbiology
Vector, per se
435455, 536 231, 536 245, C12N 1563, C12N 1585, C07H 2104
Patent
active
060571535
ABSTRACT:
Modified external guide sequence (EGS) molecules that mediate cleavage of specific target RNAs have been constructed. The modified molecules are external guide sequence molecules for RNAse P which are designed to specifically bind to and promote RNAse P-mediated cleavage of target RNA molecules and to have enhanced nuclease resistance. Specific regions are modified to achieve enhanced stability while maintaining RNAse P activity. Modified external guide sequence molecules suitable for use in the treatment of hepatitis B viral infections have been constructed.
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George Shaji T.
Goldberg Allan R.
Ma Michael
Pace Umberto
Werner Martina
Brusca John S.
Sandals William
Yale University
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