Stabilized estradiol cream composition

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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A61K 3156

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active

044367384

ABSTRACT:
Loss of potency of estradiol cream compositions found to be due to unexpected oxidation of estradiol. Improved cream composition comprises 1% or less 17.beta.-estradiol in the presence of stabilizing members selected from phenolic-type antioxidants, metal chelating agents, and suspending agents.

REFERENCES:
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patent: 4154820 (1979-05-01), Simoons
patent: 4344940 (1982-08-01), Chew et al.
Martin et al., Obstet. Gynecol., vol. 39, pp. 771-774, (1972), (1/19).
Schiff et al., Fert. Steril., 28/10, (1977), (1/21), pp. 1063-1066.
Rigg et al., J. Clin. Endocr. Metab., (1977), No. 45/6, pp. 1261-1264.

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