Stabilized controlled release substrate having a coating derived

Details Stabilized controlled release substrate having a coating derived Stabilized controlled release substrate having a coating derived

1997-07-24

2000-10-10

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424461, 424480, 424494, 42721331, A61K 962

Patent

active

061299332

ABSTRACT:
A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.

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