Stabilized controlled release substrate having a coating derived

Details Stabilized controlled release substrate having a coating derived Stabilized controlled release substrate having a coating derived

1991-12-24

1993-12-28

Webman, Edward

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424461, 424495, 5147721, 514781, 427 3, 42721331, 4273722, 427377, A61K 914, A61K 916, A61K 936, A61K 962

Patent

active

052737608

ABSTRACT:
A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of ethylcellulose is obtained by overcoating a substrate including a therapeutically active agent with an aqueous dispersion of ethylcellulose and then curing the coated substrate at a temperature and relative humidity elevated to a suitable level above ambient conditions until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.

REFERENCES:
patent: 4600645 (1986-07-01), Ghebre-Sellasie et al.
patent: 4728513 (1988-03-01), Ventouras
patent: 5019397 (1991-05-01), Wong et al.
patent: 5042842 (1991-06-01), Edgren et al.
patent: 5068110 (1991-11-01), Fawzi et al.
D. L. Munday, A. R. Fassihi, 5th Congr. Int. Technol. Pharm. vol. 2, pp. 55-60, Changes in Drug Release Rate, Effect of Temperature and Relative Humidity on Polymeric Film Coatings, 1989, Assoc. Pharm. Galenique Ind., Chatenay Malabry, FR.

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