Stabilized controlled release formulations having acrylic polyme

Details Stabilized controlled release formulations having acrylic polyme Stabilized controlled release formulations having acrylic polyme

1992-01-27

1994-02-15

Michl, Paul R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424482, 424497, 424483, A61K 962, A61K 900

Patent

active

052864936

ABSTRACT:
A stabilized solid controlled release dosage form having a coating derived from an aqueous dispersion of an acrylic polymer is obtained by overcoating a substrate including a therapeutically active with an aqueous dispersion of the plasticized acrylic polymer and then curing the coated substrate at a temperature above the glass transition temperature of the plasticized acrylic polymer, until the coated dosage form attains a stabilized dissolution profile substantially unaffected by exposure to storage conditions of elevated temperature and/or elevated relative humidity.

REFERENCES:
patent: 4600645 (1986-07-01), Ghebre-Sellassie
patent: 4728513 (1988-03-01), Ventouras
patent: 5019397 (1991-05-01), Wong et al.
patent: 5024842 (1991-06-01), Edgren et al.
patent: 5068110 (1991-11-01), Fawzi et al.

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