Stabilized compounds having secondary structure motifs

Details Stabilized compounds having secondary structure motifs Stabilized compounds having secondary structure motifs

2007-03-20

2007-03-20

Tate, Christopher R. (Department: 1654)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C514S014800, C530S300000, C530S326000, C530S327000, C530S331000, C530S332000, C530S333000, C530S334000, C530S335000, C530S336000, C530S337000, C530S338000, C556S136000

Reexamination Certificate

active

09574086

ABSTRACT:
The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the synthesis of these compounds libraries thereof. The synthesis of these novel stabilized compounds involves (1) synthesizing a peptide from a selected number of natural or non-natural amino acids, wherein said peptide comprises at least two moieties capable of undergoing reaction to promote carbon-carbon bond formation; and (2) contacting said peptide with a reagent to generate at least one crosslinker and to effect stabilization of a secondary structure motif. The present invention, in a preferred embodiment, provides stabilized p53 donor helical peptides. Additionally, the present invention provides methods for disrupting the p53/MDM2 binding interaction comprising (1) providing a crosslinked stabilized α-helical structure; and (2) contacting said crosslinked stabilized α-helical structure with MDM2.

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