Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Stabilized enzymes or enzymes complexed with nonenzyme
Patent
1997-01-22
1999-05-18
Weber, Jon P.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Stabilized enzymes or enzymes complexed with nonenzyme
424 941, 424 944, 435188, 435189, A61K38/54;38/43;38/44
Patent
active
059049219
ABSTRACT:
Germinated plant seeds are disclosed as a source of superoxide dismutase (SOD). The SOD is stabilized to temperatures of at least 45.degree. C. when combined in a stabilizing composition comprising a peroxidase, a peroxidase cofactor, and a hydrophilic substance selected from sugars and polyols of less than 2,000 g/mole in molecular mass. The stabilized SOD compositions can be used in cosmetic, pharmaceutical or food compositions. Methods of treating mammals against the harmful effects of free radicals and against inflammation are also disclosed.
REFERENCES:
patent: 3637640 (1972-01-01), Huber
patent: 3773929 (1973-11-01), Huber et al.
patent: 3997402 (1976-12-01), Michelson
patent: 5179012 (1993-01-01), Gudin et al.
patent: 5219825 (1993-06-01), Gressel et al.
patent: 5362494 (1994-11-01), Zysman et al.
patent: 5536654 (1996-07-01), Gudin et al.
J.Exp.Botany, vol. 44, No. 258, Jan. 1993 "Activities of Hydrogen Peroxide-Scavenging Enzymes in Germinating Wheat Seeds", Cakmak et al pp. 127-132.
Plant Physiol., vol. 59, No. 2, 1977 Superoxide Dismutases: Giannopolitis et al, pp. 315-318.
Physiol. Plantarum, Vo. 92, No. 3, "Four Cytosolic-type CuZn . . . " Steller et al, pp. 443-450.
Biochim. Biophys. Acta., vol. 317, No. 1, Jul. 12, 1993, "Isoenzymes of Superoxide . . . Germ", Beauchamp et al, pp. 50-64.
Biochim. Biophys. Acta., Vo. 1074, No. 2, Jul. 8, 1991, "Superoxide Anion and . . . Germination", Puntarulo et al, pp. 277-283.
Eur. J. Biochem, vol. 224, No. 1, Aug. 15, 1994, "Accumulation of Reactive . . . Seeds", Gidrol et al, pp. 21-28.
J. Am. Soc. Brewing Chem., vol. 51, No. 3, 1993, "Oxygen and Oxygen Radicals . . . Review", Bamforth et al, pp. 79-83.
Malting and Brewing Science, Chapman and Hall Ltd., Hough et al, pp. 95-105.
Database Cab Abstracts, 940708524, 1994, "The Effects of Gibberellic . . . Stages", Zeng et al, pp. 347-351.
Indian J. Exp. Biol., vol. 17, No. 7, 1979, "Effects of Glucose & 1,4-dinitrophenol . . . Bean", Ahuja et al, pp. 712-713.
Boivin Patrick
Bresson-Rival Delphine
Humbert Gerard
Linden Guy
Perrier Eric
Coletica
Weber Jon P.
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