Stabilized compositions of proteins having a free thiol moiety

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Stablizing an enzyme by forming a mixture – an adduct or a...

Reexamination Certificate

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C435S209000, C536S055100, C536S001110

Reexamination Certificate

active

07833766

ABSTRACT:
Compositions of proteins having free thiols, and methods of making and using such compositions, are described.

REFERENCES:
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patent: WO 98/22136 (1998-05-01), None
patent: WO00/76480 (2000-12-01), None
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Cleland et al., “A Specific Molar Ratio of Stabilizer to Protein is Required for Storage Stability of a Lyophilized Monoclonal Antibody”, Journal of Pharmaceutical Sciences, vol. 90(3):310-321 (2001).
Passot et al., “Physical characterisation of formulations for the development of two stable freeze-dried proteins during both dried and liquid storage”, European Journ. of Pharmaceutics and Biopharmaceutics, vol. 60(3):335-348 (2005).
Tsitsimpikou et al., “Studies of the effect of organic solvents on the stability of β-glucosidase fromFusarium oxysporum”, Biotechnology Letters, vol. 16(1):57-62 (1994).
Wang, “Lyophilization and development of solid protein pharmaceuticals”, International Journal of Pharmaceutics, vol. 203(1-2):1-60 (2000).
International Preliminary Report on Patentability mailed Aug. 21, 2008 for PCT Application PCT/US2007/061657.
Written Opinion mailed Aug. 21, 2008 for PCT Application PCT/US2007/061657.

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