Stabilized compositions having human tissue type plasminogen act

Details Stabilized compositions having human tissue type plasminogen act Stabilized compositions having human tissue type plasminogen act

1993-04-06

1994-11-22

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435219, 424 941, A61K 37547, A61K 37553, A61K 3748, C12N 950

Patent

active

053667301

ABSTRACT:
Pharmaceutical preparation of a protein with t-PA activity with an enzymatic activity of at least 0.25 MU/ml. and a pH value of 4.5 to 9 which contains a substance of the group citric acid, ascorbic acid, 2-oxoglutaric acid, fumaric acid, Tris and EDTA in a concentration of at least 0.2 mole/l., as well as a medicament based on a protein with t-PA activity and processes for its preparation.

REFERENCES:
patent: 4568544 (1986-02-01), Hasegawa et al.
patent: 4898826 (1990-02-01), Duffy et al.
patent: 4980165 (1990-12-01), Isaacs et al.
patent: 5068106 (1991-11-01), Paques et al.
patent: 5095034 (1992-03-01), Kato et al.
Methods of Enzymology--vol. 182, 1990 Academic Press Inc. Deutscher, Murray P., Guide to Protein Purification, Chap. 8, "Maintaining Protein Stability", pp. 83-86.
Ranby et al., "Blood Collection in Strong Acidic Citrate anticoagulant used in a study of dietary influence on Basal & Pa Activity" Thrombosis and Haemostasis, 62(3), pp. 917-922 (1989).

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