Stabilized compositions containing epidermal growth factor

Details Stabilized compositions containing epidermal growth factor Stabilized compositions containing epidermal growth factor

1986-11-05

1988-01-05

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 99, 424100, 514 2, 530399, 530808, 530834, 530854, C07K 1300, A61K 3522, A61K 3736

Patent

active

047177179

ABSTRACT:
Medicinal compositions containing epidermal growth factor are stabilized against loss of biological activity in the presence of moisture by including in said compositions a stabilizing amount of water-soluble cellulose polymer, preferably methylcellulose or a hydroxy alkylcellulose such as hydroxypropyl methylcellulose.

REFERENCES:
patent: 3883497 (1975-05-01), Gregory et al.
patent: 3948875 (1976-04-01), Cohen et al.
patent: 4188375 (1980-02-01), Straub
patent: 4373519 (1983-02-01), Errode et al.
patent: 4528186 (1985-07-01), Nishimura et al.
patent: 4621052 (1986-11-01), Sugimoto
Urdea et al., Proc. Natl. Acad. Sci. USA, 80, 7461-7465 (1983).
Lawn et al., Cell, 15, 1157-1174 (1978).
Savage et al., J. Biol. Chemistry, 247, 7612-7621 (1972).
Carpenter et al., Experimental Cell Research 164, 1-10 (1986).
Arakawa et al., Biochemistry, 21, 6536-6544 (1982).

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