Stabilized coated aspirin tablets

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills

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Details

514165, A61K 928

Patent

active

047160420

ABSTRACT:
Coated aspirin tablets/caplets are provided wherein acetylsalicylic acid decomposition is inhibited by incorporation therein prior to coating of citric, alginic or glutamic acids of mixtures thereof.

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Stozek, Thomasz, "Decomposition of Acetylsalicylic Acid and the Possibilities of its Stabilization in Solid Forms of the Drug", Farmacja Polska, No. 8, pp. 771-775, (1972).
Nazareth, M. R. et al, "Stability of Aspirin in Aspirin, Phenacetin, and Caffeine Tablets", J. of Pharm. Sci., vol. 50, No. 7, Jul. 1961.
Delonca, H. et al, "Influence of Excipients and Storage Conditions on Conservation of Drugs; I. Case of Acetylsalicylic Acid Based Tablets", Journal de Pharmacie de Belgique, vol. 24, pp. 243-252, (1969).
Delonca, H. et al, "Influence of Excipients and Storage Conditions on Conservation of Drugs; II. Case of Acetylsalicylic Acid Based Capsules", Journal de Pharmace de Belgique, No. 24, pp. 317-331, (1969).
Guttman, D. E., "Heterogeneous Catalysis of Aspirin Degradation in Chloroformic Solution and its Relationship to the Determination of Salicylic acid in Buffered Aspirin Products", J. of Pharmaceutical Sciences, vol. 57, No. 10, pp. 1685-1689, Oct. 1968.
Zoglio, M. A. et al, "Pharmaceutical Heterogeneous Systems III", Journal of Pharmaceutical Sciences, vol. 57, No. 11, pp. 1877-1880, (1968).
Blank, R. G. Affidavit.

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