Stabilized aqueous liquid preparations of blood coagulation fact

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530382, 435 2, 435 691, 435 696, 424529, 424530, 424531, 436 69, A61K 3514, A01N 102, C12P 2106

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active

060840749

ABSTRACT:
A stabilized aqueous liquid preparation of human blood coagulation factor XIII, prepared by recombinant DNA technology, from the group consisting of galactose, sucrose, sorbitol, glutamate, aspartate and histidine and where little reduction in biological activity occurs even when stored for a longer time.

REFERENCES:
patent: 4327086 (1982-04-01), Fukushima et al.
patent: 4470968 (1984-09-01), Mitra et al.
patent: 5204447 (1993-04-01), Bishop et al.
patent: 5612456 (1997-03-01), Bishop et al.
Bishop et al. "Human Recombinant Factor XIII from Saccharomyces cerevisiae". Journal of Biological Chemistry. vol. 265, No. 23:13888-13889, 1990.

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