Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-11-09
1990-06-05
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3150, A61K 31495
Patent
active
049314416
ABSTRACT:
A leucovorin composition having improved properties is provided by an aqueous, isotonic, sterile leucovorin calcium solution having a pH in the range 6.5-8.5 and containing as a buffer therein sodium citrate dihydrate in the amount in the range 1 mg-32 mg/mL, the leucovorin composition containing leucovorin calcium pentahydrate in the amount 6.35 mg/mL, equivalent to 5 mg/mL leucovorin content. A preferred sterile, aqueous leucovorin solution in accordance with this invention contains 6.35 mg/mL leucovorin calcium pentahydrate, 22 mg/mL sodium citrate dihydrate, the remainder being sterile water. The pH of this solution is adjusted to 8.1.+-.0.1 with 1N NaOH solution and/or 1N citric acid solution.
REFERENCES:
patent: 4350659 (1982-09-01), Riceberg
Henley III Raymond J.
Luitpold Pharmaceuticals, Inc.
Robinson Douglas W.
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