Stabilized aqueous catecholamine solutions

Details Stabilized aqueous catecholamine solutions Stabilized aqueous catecholamine solutions

1976-11-22

1979-08-14

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds hapten, hapten-carrier complex, or...

424319, 424330, A61K 3100, A61K 4700, A61K 31195, A61K 31135

Patent

active

041645707

ABSTRACT:
An aqueous solution for treating glaucoma comprises 0.1-5.0% of a specially purified catecholamine e.g., epinephrine, 0.5-5.0% of a thiol, e.g., N-acetyl-L-cysteine, an acid compound unless the thiol is acid) to solubilize the catecholamine and a base e.g., NH.sub.4 OH to bring the pH to 6.0-7.5, the solution being free from borate ions. The acid compound, if used can be e.g., lactic acid, which may be buffered with ammonium lactate, or ammonium dihydrogen phosphate; preferably alkali metal ions are avoided. Guanethidine or like compounds which potentiate epinephrine can also be present.

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The Merck Index, 8th Ed., p. 397 (1968).
Irikura et al., Chem. Abst., 75 132984(g) (1971).
Stuzka et al., Chem. Abst. 75 45272(e) (1971).
Evans et al., Chem. Abst. 77 43326(t) (1972).
Oosterhuis, Chem. Abst. 57 14384(c) (1962).
Kuechle, Chem. Abst. 59 14482(c) (1963).
Hendley et al., Chem. Abst. 64 4128(e) (1966).

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