Stabilized aqueous antimicrobial composition

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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424244, 424267, 424274, 424320, 424324, A01N 3718, A01N 3734, A01N 4336, A01N 4340

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active

042410800

ABSTRACT:
Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene glycol (e.g., polyethylene glycol 200) or an ether thereof (e.g., a mono- or di-lower alkyl and/or phenyl ether) and water are stabilized against decomposition of the halogenated amide antimicrobial by the addition of an acid or anhydride stabilizer such as acetic acid, glycolic acid, boric acid, ethylenediaminetetraacetic acid, succinic anhydride, etc. The compositions, so stabilized, exhibit reduced rates of decomposition of the halogenated amide antimicrobial relative to the corresponding non-stabilized aqueous compositions.

REFERENCES:
patent: 3689660 (1972-09-01), Burk et al.
patent: 3751444 (1973-08-01), Solem et al.
patent: 3770798 (1973-11-01), Norton
patent: 4022605 (1977-05-01), Konya et al.
Chemical Abstracts, vol. 82 (1975), p. 139619v.

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